Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).

De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.

Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, et al. Int J Cancer. 2011 Feb 15; 128(4):869-78.

Source: http://www.ncbi.nlm.nih.gov/PubMed/22735547?dopt=Abstract

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